What is the role of amphetamines in the treatment of narcolepsy?

Updated: Sep 04, 2019
  • Author: Sagarika Nallu, MD; Chief Editor: Selim R Benbadis, MD  more...
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Amphetamines are commonly used as an off-label treatment for narcolepsy. There is a clinical consensus that tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) potently reduce cataplexy; however, one meta-analysis found no good-quality evidence that antidepressants are effective for narcolepsy or improve quality of life and found scarce evidence of efficacy for cataplexy. [60]

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