Which medications in the drug class Alpha2-Adrenergic Agonists are used in the treatment of Restless Legs Syndrome?

Updated: Feb 22, 2017
  • Author: Ali M Bozorg, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Alpha2-Adrenergic Agonists

Presynaptic alpha2 -adrenergic agents stimulate alpha2 adrenoreceptors in the brainstem, activating an inhibitory neuron, which in turn results in reduced sympathetic outflow.

Clonidine hydrochloride (Catapres, Kapvay, Nexiclon XR)

Clonidine hydrochloride may be effective in primary RLS, as well as in RLS associated with uremia. However, it has no effect on PLMS.


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