According to the IRLSSG guidelines, what are the indications for alpha2-delta calcium-channel ligand in the treatment of restless leg syndrome (RLS)?

Updated: Feb 22, 2017
  • Author: Ali M Bozorg, MD; Chief Editor: Selim R Benbadis, MD  more...
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The use of alpha2-delta calcium-channel ligand should be considered for initial treatment of patients with any of the following:

  • Severe sleep disturbance (disproportionate to other symptoms)

  • Comorbid insomnia, anxiety, pain

  • A previous history of an impulse control disorder (ICD) or comorbid generalized anxiety disorder

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