Which medications cause or exacerbate the symptoms of restless legs syndrome (RLS)?

Updated: Feb 22, 2017
  • Author: Ali M Bozorg, MD; Chief Editor: Selim R Benbadis, MD  more...
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The following medications have been known to cause or exacerbate the symptoms of RLS:

  • Antidopaminergic medications (eg, neuroleptics)

  • Diphenhydramine

  • Tricyclic antidepressants (TCAs)

  • Selective serotonin reuptake inhibitors (SSRIs)

  • Serotonin-norepinepherine reuptake inhibitors (SNRIs)

  • Alcohol

  • Caffeine

  • Lithium

  • Beta blockers

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