Which lab tests should be performed when a secondary cause of restless legs syndrome (RLS) is suspected?

Updated: Feb 22, 2017
  • Author: Ali M Bozorg, MD; Chief Editor: Selim R Benbadis, MD  more...
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If a secondary cause of RLS is suspected on the basis of history, abnormal findings on neurologic examination, or poor response to treatment, other laboratory tests should be done. These include a complete blood count (CBC) and measurement of levels of the following:

  • Blood urea nitrogen (BUN)

  • Creatinine

  • Fasting blood glucose

  • Magnesium

  • Thyroid-stimulating hormone (TSH)

  • Vitamin B-12

  • Folate

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