What is the role of GABA reuptake inhibitors in the treatment of epilepsy?

Updated: Jan 28, 2020
  • Author: Juan G Ochoa, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Answer

Reuptake of gamma-aminobutyric acid (GABA) is facilitated by at least 4 specific GABA-transporting compounds; these carry GABA from the synaptic space into neurons and glial cells, where it is metabolized. Nipecotic acid and tiagabine (TGB) are inhibitors of these transporters; this inhibition makes increased amounts of GABA available in the synaptic cleft. GABA prolongs inhibitory postsynaptic potentials (IPSPs).


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