What are the mechanisms of action and pharmacokinetics of SV2A-binding agents?

Updated: Jan 28, 2020
  • Author: Juan G Ochoa, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Answer

Synaptic vesicle protein 2A (SV2A) is ubiquitously expressed in the brain, but its function has not been clearly defined. SV2A appears to be important for the availability of calcium-dependent neurotransmitter vesicles ready to release their content. [4] The lack of SV2A results in decreased action potential-dependent neurotransmission, while action potential–independent neurotransmission remains normal. [5, 6]

The role of SV2A in epilepsy is confirmed by the finding that SV2A knockout mice develop a strong seizure phenotype a few weeks after birth. [5, 6] The anticonvulsant potency of SV2A ligands is correlated with their binding affinity in the audiogenic seizure-prone mice. [7, 8] Levetiracetam binds the SV2A.


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