What are the mechanisms of action and pharmacokinetics of SV2A-binding agents?

Updated: Jan 28, 2020
  • Author: Juan G Ochoa, MD; Chief Editor: Selim R Benbadis, MD  more...
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Synaptic vesicle protein 2A (SV2A) is ubiquitously expressed in the brain, but its function has not been clearly defined. SV2A appears to be important for the availability of calcium-dependent neurotransmitter vesicles ready to release their content. [4] The lack of SV2A results in decreased action potential-dependent neurotransmission, while action potential–independent neurotransmission remains normal. [5, 6]

The role of SV2A in epilepsy is confirmed by the finding that SV2A knockout mice develop a strong seizure phenotype a few weeks after birth. [5, 6] The anticonvulsant potency of SV2A ligands is correlated with their binding affinity in the audiogenic seizure-prone mice. [7, 8] Levetiracetam binds the SV2A.

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