How is euthyroid sick syndrome treated?

Updated: Oct 08, 2018
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Thyroid hormones have been used in the setting of NTI in various settings with T4 and T3 replacement and still remain controversial. De Groot has supported the notion that nonthyroidal illness syndrome is a manifestation of hypothalamic-pituitary dysfunction, and in view of current evidence, he proposed that treatment should be considered with appropriate replacement therapies such as pituitary hormones, hypothalamic factors in addition to thyroid hormones. [28]

A randomized, doubled-blind, placebo-controlled trial by Zhang et al reported that in children who underwent congenital heart disease repair with cardiopulmonary bypass, the severity of postoperative euthyroid sick syndrome was reduced when oral, small-dose thyroid hormone treatment was administered preoperatively. [29]

A retrospective study by Li et al indicated that in patients with nonthyroidal illness syndrome associated with enterocutaneous fistula, enteral nutrition therapy can contribute to the syndrome’s resolution. [30]


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