What is the role of malignancy in the development of euthyroid sick syndrome?

Updated: Oct 08, 2018
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

The severity, the type, and the stage of malignancy affect a thyroid function test in various ways. Effects on thyroid function test results also are associated with nutritional status, medications, and treatment types. Generally, total T4 is unchanged, free T4 is increased or unchanged, total T3 is decreased, free T3 is unchanged, rT3 is elevated, basal TSH is unchanged, and TSH response to TRH is unchanged.


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