Which drugs influence thyroid function in euthyroid sick syndrome?

Updated: Apr 27, 2017
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Drugs that influence thyroid function include the following:

  • Drugs that decrease thyroid-stimulating hormone secretion - Dopamine, glucocorticoids, octreotide
  • Drugs that decrease thyroid hormone secretion - Lithium, iodide, amiodarone, aminoglutethimide
  • Drugs that increase thyroid hormone secretion - Iodide, amiodarone
  • Drugs that decrease thyroxine absorption - Colestipol, cholestyramine, aluminum hydroxide, ferrous sulphate, sucralfate
  • Drugs that alter thyroxine and triiodothyronine transport in serum (increased serum thyroxine-binding globulin concentration) - Estrogens, tamoxifen, heroin, methadone, mitotane, fluorouracil
  • Drugs that alter thyroxine and triiodothyronine transport in serum (decreased serum thyroxine-binding globulin concentration) - Androgens, anabolic steroids, slow-release nicotinic acid, glucocorticoids
  • Drugs that alter thyroxine and triiodothyronine transport in serum (displacement from protein-binding sites) - Furosemide, fenclofenac, mefenamic acid, salicylates
  • Drugs that alter thyroxine and triiodothyronine metabolism (increased hepatic metabolism) - Phenobarbital, rifampin, phenytoin, carbamazepine
  • Drugs that alter thyroxine and triiodothyronine metabolism (decreased thyroxine 5'-deiodinase activity) - Propylthiouracil, amiodarone, beta-adrenergic antagonist drugs

Conditions that affect thyroid function tests

Certain thyroid function test result abnormalities also have been characterized in the conditions and NTIs.


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