What is the role of thyroid hormone receptor expression in the pathophysiology of euthyroid sick syndrome?

Updated: Oct 08, 2018
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

In experimental mouse liver models, infection decreased thyroid hormone receptor (TR) expression as well as retinoid X receptor (RXR)–TR DNA binding. TR-alpha and TR-beta protein levels were both decreased when lipopolysaccharide was administered, particularly at 16 hours. Lipopolysaccharide exposure was also shown to reduce RXR protein levels in the liver. [11]


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