What is the role of thyroxine-binding globulin in the pathophysiology of euthyroid sick syndrome?

Updated: Apr 27, 2017
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

T4-binding globulin (TBG) is a member of the serine protease inhibitors. Diminished T4 in NTI has been proposed to be due to low TBG caused by protease cleavage at inflammatory sites in acute inflammatory conditions. One other hypothesis for the cause of disproportionately low serum T4 concentrations in patients with NTI is the presence of abnormal serum binding due to desialation of TBG.


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