Which medications in the drug class Anticonvulsants, Benzodiazepine are used in the treatment of Epilepsy and Seizures?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Anticonvulsants, Benzodiazepine

These agents bind to the gamma-aminobutyric acid (GABA) receptor, thereby enhancing the actions of GABA.

Clobazam (ONFI)

Clobazam is a 1,5-benzodiazepine that possesses potent anticonvulsant properties. Its mechanism of action is binding to the gamma-aminobutyric acid–A (GABA-A) receptor. This agent is thought to potentiate GABAergic neurotransmission. The active metabolite, N-demethylclobazam, is largely responsible for its long duration of action. Clobazam is indicated for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients older than 2 years.

Midazolam intranasal (Nayzilam)

Short-acting, water-soluble imidazobenzodiazepine. Thought to potentiate GABAergic neurotransmission which results from binding at the benzodiazepine site of the GABA-A receptor. It is indicated for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in adults and children aged 12 years or older with epilepsy.

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