What is the role of lesionectomy in the treatment of epilepsy?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

In a study presented at the 66th Annual Meeting of the American Epilepsy Society, investigators suggested that, in select pediatric patients, smaller lesionectomy resections in the surgical treatment of seizures may be as effective as larger resections, and they may spare children the functional and developmental deficits associated with the larger resections. [72, 73]

The researchers reported on the outcomes of 25 children with MRI-negative, intractable partial epilepsy who underwent focal corticectomies. Epileptogenic regions were identified by 3-dimensional EEG, single-photon emission computed tomography (SPECT) scanning, positron emission tomography (PET) scanning, and invasive EEG data. Seizure-free outcomes occurred in 3 of 7 patients with type I focal cortical dysplasia, 7 of 12 patients with type II focal cortical dysplasia, and 3 of 6 patients with mild malformations of cortical development. [72, 73]


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