What is the efficacy of immunotherapy for the treatment of medically refractory epilepsy?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Of the patients in group 2 who received (1) immunotherapy with intravenous (IV) steroids and IV immunoglobulin for 6 months, (2) IV methylprednisolone, IV immunoglobulin, and rituximab, or (3) IV steroids, 5 cycles of plasmapheresis, and oral steroids, 75% had a reduction in seizure frequency of 50% or greater. [56] The remaining patients in group 2 who received immunotherapy were evenly distributed between those who had a reduction in seizure frequency of 20-50% and those with a reduction of less than 20%. [56]


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