Which anticonvulsants are used to treat tonic or atonic seizures?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Tonic or atonic seizures are dramatic seizures. Patients with Lennox-Gastaut syndrome may have seizures, and this syndrome is best treated with broad-spectrum drugs (eg, valproic acid, lamotrigine, topiramate) or felbamate as a last resort. Other treatment modalities include the use of vagal nerve stimulation (VNS). The US Food and Drug Administration (FDA) has approved several agents—rufinamide, clobazam, [35]  extended-release topiramate, [36, 37, 38, 39] cannabidiol, [81, 82]  and stiripentol [83]  —as adjunctive therapies for seizures associated with Lennox-Gastaut syndrome or Dravet syndrome.

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