Why do serum antiepileptic drug (AED) baseline trough levels decrease over time?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
  • Print
Answer

After an anticonvulsant has been used for several weeks, the baseline trough serum concentration slowly decreases because of hepatic autoinduction; this phenomenon is most often seen with carbamazepine, oxcarbazepine, and lamotrigine. Adding other medications with similar metabolic pathways may substantially change the clearance of some anticonvulsants.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!