Why do serum antiepileptic drug (AED) baseline trough levels decrease over time?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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After an anticonvulsant has been used for several weeks, the baseline trough serum concentration slowly decreases because of hepatic autoinduction; this phenomenon is most often seen with carbamazepine, oxcarbazepine, and lamotrigine. Adding other medications with similar metabolic pathways may substantially change the clearance of some anticonvulsants.

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