What are the American Academy of Neurology (AAN) recommendations for the use of prolactin to diagnose epileptic seizures?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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The American Academy of Neurology (AAN) recommends serum prolactin assays, measured in the appropriate clinical setting at 10-20 minutes after a suspected event as a useful adjunct for differentiating generalized tonic-clonic or complex partial seizure from psychogenic nonepileptic seizure in adults and older children. [32]

The AAN notes, however, that prolactin assays do not distinguish epileptic seizures from syncope and have not been established in the evaluation of status epilepticus, repetitive seizures, and neonatal seizures. [32] It should also be noted that wider availability of bedside video electroencephalography (EEG), the gold standard, has replaced prolactin testing for the evaluation of epileptic versus nonepileptic episodes.

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