What causes autosomal dominant nocturnal frontal lobe epilepsy?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Autosomal dominant nocturnal frontal lobe epilepsy is caused by mutations in the CHRNA4, CHRNB2, or CHRNA2 genes. It is characterized by nocturnal motor seizures. The severity of autosomal dominant nocturnal frontal lobe epilepsy can be variable, can include awakening episodes, and can result in impressive dystonic effects. Affected individuals are generally otherwise normal, and the attacks tend to become less severe with age.


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