What is the prevalence of seizures in Wolf-Hirschhorn syndrome?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Wolf-Hirschhorn syndrome is caused by deletions of chromosome 4p16.3. Typical facies in these patients include a broad nasal bridge continuing to the forehead (the “Greek warrior helmet” appearance), microcephaly, high forehead, hypertelorism, and highly arched eyebrows. The mouth tends to be turned downward. Growth retardation is seen, as is a variable degree of intellectual disability. Although seizures are present in between 50-100% of patients with Wolf-Hirschhorn syndrome, they tend to improve with age. [20]


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