Which mechanisms lead to increased excitation in the pathophysiology of epilepsy?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Mechanisms leading to increased excitation include the following:

  • Increased activation of NMDA receptors

  • Increased synchrony between neurons due to ephaptic interactions

  • Increased synchrony and/or activation due to recurrent excitatory collaterals


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