Which pathophysiologic mechanisms cause focal-onset epileptic seizures?

Updated: May 30, 2019
  • Author: David Y Ko, MD; Chief Editor: Selim R Benbadis, MD  more...
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The following mechanisms (discussed below) may coexist in different combinations to cause focal-onset seizures:

  • Decreased inhibition

  • Defective activation of gamma-aminobutyric acid (GABA) neurons

  • Increased activation

If the mechanisms leading to a net increased excitability become permanent alterations, patients may develop pharmacologically intractable focal-onset epilepsy.

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