What is the role of caffeine in seizures?

Updated: Jun 14, 2018
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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As mentioned earlier, caffeine acts as a central nervous stimulant by blocking A1 and A2A adenosine receptors. Its effect on seizures is complex. Animal studies and case reports indicate that acute caffeine exposure may induce seizures, whereas chronic exposure might have an opposite effect. In a recent study by Samsonsen et al, no difference was found between the intake of caffeine 24 hours prior to the seizure and the habitual consumption or the consumption on a seizure-free day. In essence, caffeine does not appear to be a common seizure precipitant. [17]

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