Which medications in the drug class Presynaptic Dopamine-Depleting Agents are used in the treatment of Tourette Syndrome and Other Tic Disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

Presynaptic Dopamine-Depleting Agents

These agents suppress tics. They are presynaptic depleting agents that have acute adverse effects similar to neuroleptics but theoretically may avoid the risk of tardive dyskinesia.

Tetrabenazine (Xenazine)

This agent depletes neurotransmitter stores of dopamine, serotonin, and noradrenaline within nerve cells in the brain, thereby altering the transmission of electric signals from the brain that control movement by reversibly inhibiting vesicular monoamine transporter 2 (VMAT2).


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