Which medications in the drug class Neuromuscular Blockers are used in the treatment of Tourette Syndrome and Other Tic Disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

Neuromuscular Blockers

These agents suppress tics and possibly premonitory sensations.

OnabotulinumtoxinA (BOTOX)

This agent inhibits release of acetylcholine at neuromuscular junction; it is injected directly into muscle. It is most useful for dystonic tics (eg, sustained eye closure) or only 1 or 2 especially problematic tics (eg, repeatedly flinging head to 1 side causing neck pain and broken glasses). Tics and tic urges may improve; effect can be seen in absence of gross weakness. Successful outcomes require substantial specialized experience in the treating physician.


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