What is the role of naltrexone/naloxone in the treatment of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

Naltrexone/naloxone have been reported helpful in a few patients, but other studies have shown transient worsening of tics with opioid antagonists. [194, 195] An RCT of naloxone showed some benefit at low doses, but worsening of tics at higher doses. [196] Case reports also have described benefit with opioid agonists. [197, 198]


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