What is the role of botulinum toxin injections in the treatment of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Botulinum toxin injections and oral baclofen were initially the subject of enthusiastic retrospective reports, but blinded trials of these 2 agents have revealed statistically significant but clinically modest benefit compared with placebo. [183] Botulinum toxin injections may improve urges or sensory tics, as well as observable tics, and it may be the treatment of choice for patients with a single, especially problematic, dystonic tic.

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