What is the role of topiramate in the treatment of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

A double-blind, placebo-controlled study examined topiramate at a dosage of about 100 mg/day, and concluded that it may be safe and effective in decreasing Total Tic Score, but noted that a larger study with longer followup than their 10 weeks was needed. [179] However, a Chinese meta-analysis of 9 randomized controlled trials did not show significant difference in reducing tic occurrence between topiramate and haloperidol or tiapride. [180]


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