What is the role of guanfacine and clonidine in the treatment of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Guanfacine was tested in an RCT in children with both ADHD and chronic tic disorders and was found to be clearly superior to placebo in the reduction of both ADHD and tic symptoms (31% on average), with few adverse effects. [177] This drug also has been shown to be efficacious in adults with nontic ADHD.

Clonidine has frequently been used to treat tics. A large RCT confirmed its efficacy for both ADHD symptoms and tics in patients with TS. [178] Clonidine or guanfacine may be appropriate as a first agent in many patients.

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