What is the role of dopamine agonist therapy in the treatment of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Paradoxically, several mixed dopamine agonists have also been proven effective in reducing tic frequency. [23, 167, 25] To date, they have been tested exclusively in relatively low doses, partly because of a theory that, at these doses, they must antagonize dopamine function by selective action at presynaptic receptors.

Accumulating evidence suggests that this rationale is faulty, however, and trials with higher doses may be expected.

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