Which autopsy findings have increased the understanding of the pathophysiology of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
  • Print
Answer

A limited number of autopsied cases have shown a reduction in tonically active parvalbumin-positive interneurons in the caudate and putamen. Postmortem studies have also shown a doubling of the parvalbumin-positive projections from the globus pallidus interna to the thalamus.

Although the importance of these findings is uncertain, parvalbumin is known to be a marker for fast-spiking interneurons that have widespread influence. These neurons are thought to be output neurons and their reduction could diminish output from the globus pallidus interna.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!