What is the role of focal lesions in the pathophysiology of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Several cases of tics beginning after a focal lesion to the prefrontal cortex, basal ganglia, and thalamus have been reported. One series described 6 patients who suddenly developed tics, obsessions, and/or compulsions after anaphylactic reaction to wasp stings produced bilateral globus pallidus lesions. [67, 68]

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