Which findings on functional imaging suggest deficient striatal activation in the pathophysiology of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

In 2001, Rauch and colleagues reported findings from a pilot study in which TS patients (like patients with OCD) showed deficient activation of striatum during implicit learning. [65]

In the same year, Swerdlow and colleagues developed a method for imaging brain function during prepulse inhibition of the startle reflex, a well-studied phenomenon that requires striatal activation. [66]


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