What is the role of metabolism in the pathophysiology of Tourette syndrome (TS) and other tic disorders?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Several groups compared patients with TS with control subjects in terms of regional resting brain function, as indexed by blood flow or metabolism. [38] The results suggested no alteration in average whole-brain activity, but some relatively consistent regional differences were found. Increased activity was observed in primary sensorimotor cortex, which may be a nonspecific reflection of excessive movement. All groups found decreased activity in the basal ganglia, perhaps best localized to ventral striatum. [49, 50, 51, 52, 53, 54, 55]

Some investigators found increased activity in the orbital frontal cortex. [56, 57] Others, however, found decreased orbital activity. [49]

Eidelberg et al examined the correlation of metabolism among specific brain regions and showed differences between TS and controls, some of which related specifically to tic severity. [58]

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