What is the role of amphetamines in the pathophysiology of Tourette syndrome (TS)?

Updated: May 30, 2019
  • Author: William C Robertson, Jr, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

Singer et al demonstrated normal dopamine release at baseline in TS but altered dopamine release in response to a pharmacologic challenge with amphetamine. [40] This observation may explain the essentially normal neurologic function seen in TS when tics are not apparent.


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