What is the role of lab studies in the evaluation of moyamoya disease?

Updated: Nov 09, 2018
  • Author: Roy Sucholeiki, MD; Chief Editor: Amy Kao, MD  more...
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Several studies may be indicated in patients with moyamoya disease. In a patient with stroke of unclear etiology, a hypercoagulability profile may be helpful. Significant abnormality in any of the following is a risk factor for ischemic stroke:

  • Protein C

  • Protein S

  • Antithrombin III

  • Homocysteine

  • Factor V Leiden

The erythrocyte sedimentation rate (ESR) can be obtained as part of the initial workup of possible vasculitis. However, a normal ESR does not rule out vasculitis.

Thyroid function and thyroid autoantibody levels have been shown to be elevated in a significant percentage of pediatric patients with moyamoya disease. [11] Therefore, monitoring these studies is indicated.

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