Which medications in the drug class Antidiabetics, Amylinomimetics are used in the treatment of Type 2 Diabetes Mellitus?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Antidiabetics, Amylinomimetics

These agents mimic endogenous amylin effects by delaying gastric emptying, decreasing postprandial glucagon release, and modulating appetite.

Pramlintide (Symlin, SymlinPen 120, SymlinPen 60)

This agent is a synthetic analogue of human amylin, a naturally occurring hormone made in pancreatic beta cells. It slows gastric emptying, suppresses postprandial glucagon secretion, and regulates food intake because of centrally mediated appetite modulation.

Pramlintide is indicated for the treatment of type 1 or type 2 diabetes in combination with insulin. It is administered before mealtime in patients who have not achieved desired glucose control despite optimal insulin therapy. It helps to achieve lower blood glucose levels after meals, less fluctuation of blood glucose levels during the day, and improvement of long-term control of glucose levels (ie, HbA1C levels), compared with insulin alone. Additionally, less insulin use and a reduction in body weight are observed.

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