Which medications in the drug class Antidiabetics, Alpha-Glucosidase Inhibitors are used in the treatment of Type 2 Diabetes Mellitus?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Antidiabetics, Alpha-Glucosidase Inhibitors

Alpha-glucosidase inhibitors prolong the absorption of carbohydrates and thus help to prevent postprandial glucose surges. Their induction of flatulence greatly limits their use. Doses of these agents should be titrated slowly to reduce GI intolerance. Their effect on glycemic control is modest, affecting primarily postprandial glycemic excursions.

Acarbose (Precose)

Acarbose was the first alpha-glucosidase inhibitor approved by the FDA. It is absorbed to a small degree, so liver function abnormalities can occur rarely. It can be used as monotherapy or in combination with other treatment modalities. The modest effect of acarbose on glycemia and its high degree of GI adverse effects (flatulence) limit its use.

Miglitol (Glyset)

Miglitol is not absorbed, so liver function abnormalities do not occur. It is FDA approved for use as monotherapy or in combination with sulfonylureas. Its modest effect on glycemia and high degree of GI adverse effects (flatulence) limit its use.

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