What drugs are used in the treatment of type 2 diabetes mellitus (DM)?

Updated: Oct 23, 2019
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Pharmacologic therapy of type 2 diabetes has changed dramatically in the last 10 years, with new drugs and drug classes becoming available. These drugs allow for the use of combination oral therapy, often with improvement in glycemic control that was previously beyond the reach of medical therapy.

Agents used in diabetic therapy include the following:

  • Biguanides

  • Sulfonylureas

  • Meglitinide derivatives

  • Alpha-glucosidase inhibitors

  • Thiazolidinediones (TZDs)

  • Glucagonlike peptide–1 (GLP-1) agonists

  • Dipeptidyl peptidase IV (DPP-4) Inhibitors

  • Selective sodium-glucose transporter-2 (SGLT-2) inhibitors

  • Insulins

  • Amylinomimetics

  • Bile acid sequestrants

  • Dopamine agonists


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