What effect does cigarette smoking have on type 2 diabetes mellitus (DM) risk?

Updated: Jul 13, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Yeh et al found that although cigarette smokers are at increased risk for type 2 diabetes, smoking cessation leads to higher short-term risk. [373] In this prospective cohort study in 10,892 middle-aged, nondiabetic adults, 1254 persons developed type 2 diabetes during 9 years of follow up.

The adjusted hazard ratio of incident diabetes among persons in the highest tertile of pack-years was 1.42, compared with persons who had never smoked. However, in the first 3 years after quitting smoking, the hazard ratio was 1.73; the risk then gradually decreased, disappearing completely at 12 years. Yeh et al recommended that smoking cessation in smokers at risk for diabetes be coupled with strategies for prevention and early detection of diabetes.

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