How do modest lifestyle improvements decrease the risk of type 2 diabetes mellitus (DM)?

Updated: Jul 13, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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The Diabetes Prevention Program (DPP) trial has shown that modest lifestyle changes (eg, 4-5% sustained weight reduction for approximately 3 y) reduce the risk for diabetes in patients at high risk by 58%. [370] Eight health-care facilities participated in an instructive study of group-based lifestyle intervention that should help other agencies/states emulate strategies used to affect positive lifestyle changes for the prevention of diabetes. [371]

In an 11-year, population-based cohort study of over 200,000 men and women without evidence of diabetes, heart disease, or cancer at baseline, good lifestyle decisions in combination significantly reduced the risk of developing diabetes. For each additional positive lifestyle factor (eg, with regard to diet, physical activity, or smoking) in the low-risk group, the odds for diabetes were 31% lower [372]

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