Which patient subgroups are most at risk for development of type 2 diabetes mellitus (DM) complications?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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A study by Cigolle et al found that middle-aged and older adults with diabetes have an increased risk for the development of geriatric conditions (eg, cognitive, vision, and hearing impairments; falls). [328] These conditions substantially contribute to morbidity and functional impairment. The authors concluded that adults with diabetes should be monitored for the development of geriatric conditions at a younger age than was previously considered.

The risk for early development of Parkinson disease is 36% higher in patients with diabetes mellitus. [329] However, a systematic review from Cereda et al found no conclusive evidence of this association. [330]

A high overall risk for pancreatic neoplasm is noted in individuals with diabetes mellitus, particularly in those aged 45-65 years. [331]

The incidence of complications widely vary among the Asian subgroups, suggesting the need for an ethnic stratified nuanced approach in evaluation and surveillance. [332] One size does not fit all.

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