How effective are premixed insulin analogues in the treatment of type 2 diabetes mellitus (DM)?

Updated: Jul 13, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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A range of insulin preparations, individual and premixed, is currently available. The Agency for Healthcare Research and Quality (AHRQ) has reviewed the use of premixed insulin analogues in patients with type 2 diabetes mellitus. Conclusions for which the strength of evidence was high are as follows [262] :

  • For lowering postprandial glucose, premixed insulin analogues are more effective than either long-acting insulin analogues alone or premixed neutral protamine Hagedorn (NPH)/regular human insulin 70/30

  • For lowering HbA1c, premixed insulin analogues are as effective as premixed NPH/regular human insulin 70/30 and more effective than long-acting insulin analogues

  • The frequency of hypoglycemia reported with premixed insulin analogues is similar to that with premixed human insulin and higher than that with oral antidiabetic agents

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