When is dulaglutide contraindicated for type 2 diabetes mellitus (DM)?

Updated: Dec 04, 2019
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Dulaglutide is not recommended for use as first-line pharmacologic treatment for type 2 diabetes, and it is contraindicated in patients with personal or family history of medullary thyroid carcinoma or in those with multiple endocrine neoplasia syndrome type 2. [176] The label will include a boxed warning that thyroid C-cell tumors have been observed in animal studies. Required postmarketing studies will include studies in children, a medullary thyroid carcinoma case registry, and a cardiovascular outcomes study in high-risk patients. [176]


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