What is the role of liraglutide in the treatment of type 2 diabetes mellitus (DM)?

Updated: Oct 23, 2019
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Indicated as an adjunct to diet and exercise, liraglutide therapy is aimed at improving glycemic control in adults with type 2 diabetes. In addition, results from the LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) clinical trial led to liraglutide’s approval for risk reduction of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease. With a median follow-up of 3.8 years, risk for the trial’s composite endpoint of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke was 13.0% for patients treated with liraglutide, compared with 14.9% for those given placebo therapy. [168]

In June 2019, liraglutide was approved by the FDA for use in children aged 10 years or older with type 2 diabetes. Approval was based on the ELLIPSE clinical trial, in which patients aged 10 years to less than 17 years received up to 1.8 mg/day of subcutaneous liraglutide or placebo. After 26 weeks, the mean HbA1c level was 0.64% lower in the liraglutide patients and 0.42% higher in the placebo patients. [169]


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