Do metformin and insulin reduce inflammatory biomarker levels in recent-onset type 2 diabetes mellitus (DM)?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Pradhan et al did not find an association between improvement of glycemic control with metformin or insulin and reduction of inflammatory biomarker levels in patients with recent-onset type 2 diabetes. [184] Patients were randomized to 1 of 4 groups: placebo, placebo plus insulin glargine, metformin only, and metformin and insulin glargine. No difference in levels of the inflammatory biomarker high-sensitivity C-reactive protein was shown between study participants who received insulin or metformin and those who did not.

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