Are autoantibodies useful in differentiating type 1 and type 2 diabetes mellitus (DM)?

Updated: Jul 13, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Autoantibodies can be useful in differentiating between type 1 and type 2 diabetes. Islet-cell (IA2), anti-GAD65, and anti-insulin autoantibodies can be present in early type 1 diabetes, but not in type 2 disease. IA2 autoantibodies titers typically decrease after 6 months. Anti-GAD65 antibodies can be present at diagnosis of type 1 diabetes and are more likely to be persistently positive over time.

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