How is latent autoimmune diabetes of adults (LADA) differentiated from type 2 diabetes mellitus (DM)?

Updated: Jul 13, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Latent autoimmune diabetes of adults (LADA) is a form of slow-onset type 1 diabetes that occurs in middle-aged (usually white) adults. It can be differentiated from type 2 diabetes by confirming the presence of antibodies against the 65-kd isoform of glutamic acid decarboxylase (GAD65), an enzyme found in pancreatic beta cells. Such patients may respond to insulin secretagogues for a brief period (months).

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