How does metabolic syndrome (also called syndrome X or the insulin-resistance syndrome) progress into insulin resistance?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Eventually, clinically apparent insulin resistance develops. Unfortunately, insulin resistance is not possible to measure clinically, except in research settings. An elevated fasting blood glucose or triglyceride level may be the first indication of insulin resistance. Fasting insulin levels are generally increased at an earlier stage, but they are more directly related to insulin clearance than to insulin resistance. An effort to standardize insulin assays is under way and may allow for the use of fasting insulin levels to diagnose insulin resistance in the future.

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