What is the risk of coronary heart disease (CHD) in adults with type 2 diabetes mellitus (DM)?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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The risk for coronary heart disease (CHD) is 2-4 times greater in patients with diabetes than in individuals without diabetes. Cardiovascular disease is the major source of mortality in patients with type 2 diabetes mellitus. Approximately two thirds of people with diabetes die of heart disease or stroke. Men with diabetes face a 2-fold increased risk for CHD, and women have a 3- to 4-fold increased risk.

Although type 2 diabetes mellitus, both early onset (< 60 y) and late onset (>60 y), is associated with an increased risk of major CHD and mortality, only the early onset type (duration >10 y) appears to be a CHD risk equivalent. [100]

In patients with type 2 diabetes mellitus, a fasting glucose level of more than 100 mg/dL significantly contributes to the risk of cardiovascular disease and death, independent of other known risk factors. [101] This is based on a review of 97 prospective studies involving 820,900 patients.

Data from a large population-based study affirms that worsening glycemic control appears to increase the risk of heart failure. [102]

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